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If amyloidosis affects your heart's electrical system, your heart rhythm may be disturbed. Less blood is pumped with each beat, and you may experience shortness of breath. Amyloid reduces your heart's ability to fill with blood between heartbeats. The potential complications of amyloidosis depend on which organs the amyloid deposits affect. People of African descent appear to be at higher risk of carrying a genetic mutation associated with a type of amyloidosis that can harm the heart. This condition is less common with more modern dialysis techniques. If you're on dialysis, abnormal proteins can build up in your blood and eventually be deposited in tissue. Dialysis can't always remove large proteins from the blood. Some types of amyloidosis are hereditary. Having a chronic infectious or inflammatory disease increases your risk of AA amyloidosis. Most people diagnosed with amyloidosis are between ages 60 and 70, although earlier onset occurs. Correct diagnosis is important so that treatments that affect the entire body can be avoided.ДЇactors that increase your risk of amyloidosis include: Typical sites for localized amyloidosis include the bladder, skin, throat or lungs. This type of amyloidosis often has a better prognosis than the varieties that affect multiple organ systems. It can also cause carpal tunnel syndrome. Formerly known as senile systemic amyloidosis, wild-type amyloidosis tends to affect men over age 70 and typically targets the heart. This variety of amyloidosis occurs when the TTR protein made by the liver is normal but produces amyloid for unknown reasons. This protein is called transthyretin (TTR). It most commonly happens when a protein made by your liver is abnormal. This inherited disorder often affects the nerves, heart and kidneys.

Hereditary amyloidosis (familial amyloidosis).

It most commonly affects the kidneys, liver and spleen. Improved treatments for severe inflammatory conditions have resulted in a sharp decline in the number of cases of AA amyloidosis in developed countries. Also known as secondary amyloidosis, this variety is usually triggered by an inflammatory disease, such as rheumatoid arthritis. It usually affects the heart, kidneys, liver and nerves. The most common type of amyloidosis in developed countries, AL amyloidosis is also called primary amyloidosis.

AL amyloidosis (immunoglobulin light chain amyloidosis).

Many types affect multiple organs, while others affect only one part of the body. Others are caused by outside factors, such as inflammatory diseases or long-term dialysis. There are many different types of amyloidosis. Request an Appointment at Mayo Clinic Causes See your doctor if you persistently experience any of the signs or symptoms associated with amyloidosis.

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Skin changes, such as thickening or easy bruising, and purplish patches around the eyes.

An enlarged tongue, which sometimes looks rippled around its edge.Unintentional weight loss of more than 10 pounds (4.5 kilograms).Diarrhea, possibly with blood, or constipation.Numbness, tingling or pain in your hands or feet, especially pain in your wrist (carpal tunnel syndrome).Unable to lie flat in bed due to shortness of breath.

Shortness of breath with minimal exertion.

Signs and symptoms of amyloidosis may include: When signs and symptoms are evident, they depend on which of your organs are affected. You may not experience signs and symptoms of amyloidosis until the condition is advanced. It can sometimes also appear rippled along its edge. An enlarged tongue (macroglossia) can be a sign of amyloidosis.